How Long Does Viagra Last: Sildenafil Wikipedia

Jun 17, 2019 Viagra

How Long Does Viagra Last: Sildenafil Wikipedia

Content:

How Long Does Viagra Last: Sildenafil Wikipedia

Sildenafil – Wikipedia cost of viagra

Coated tablets.

Pharmacological action [edit | edit code]

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Selective inhibitor of cGMP-specific PDE5, which is responsible for the disintegration of cGMP in the cavernous body of the penis. Actively enhances the relaxing effect of nitric oxide on the smooth muscles of the cavernous body and increases blood flow to the penis. When activated, the NO-cGMP chain, which is observed during sexual arousal, inhibition of PDE5 leads to an increase in cGMP in the cavernous body. The pharmacological effect is achieved only in the presence of sexual stimulation. Activity against PDE5 is 10–10,000 times greater than activity order viagra online against other PDE isoenzymes (1, 2, 3, 4, 6).

Clinical efficacy [edit | edit code]

Numerous clinical trials have shown that sildenafil is effective for erectile dysfunctions.

Pharmacokinetics [edit | edit code]

TCmax after ingestion, on an empty stomach – 0.5-2 hours, bioavailability – 25-60%. When taken with fatty foods, Cmax decreases by 20-40% and is reached in 1.5-3 hours. The volume of distribution in the equilibrium state is 105 liters. Communication with plasma proteins – 96%. Metabolized mainly by CYP3A4, CYP3A5, CYP3A7 (main route) and CYP2C9 (additional path) of microsomal liver viagra generic name isoenzymes with the formation of metabolites. The main circulating active metabolite is N-desmethylmetabolite, the activity of which is 50% of the activity of sildenafil. Overall clearance – 41 l / h. T1 / 2 of sildenafil and N-desmethylmetabolite – 3-5 hours. It is displayed in the form of inactive metabolites with feces (80%) and kidneys (15%). In patients with renal insufficiency (QC less than 30 ml / min.), Cirrhosis of the liver and in elderly people, the clearance of sildenafil is reduced.

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Indications for use [edit | edit code]

Erectile dysfunction of various etiologies (organic, psychogenic, mixed). Impotence. Treatment of pulmonary hypertension.

Contraindications [edit | edit code]

How Long Does Viagra Last: Sildenafil Wikipedia

Hypersensitivity; simultaneous reception of donators of nitric oxide or nitrates in any forms. With caution: heart disease, anatomical deformities of the is viagra government funded penis, sickle cell anemia, multiple myeloma, leukemia, childhood.

Dosing regimen [edit | edit code]

Inside, about 1 hour before planned sexual activity. Single dose for adults – 50 mg 1 time per day. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg. The maximum single dose – 100 mg. In patients with impaired liver or kidney function and in elderly viagra canada patients, dose adjustment is not required.

Overdose [edit | edit code]

An overdose of sildenafil may be accompanied by rare cases of vision loss. According to research results, the drug at the microscopic level damages the cells of the retina, which are responsible for the perception of color. As scientists proved, the damage pattern was similar to that observed with genetic retinal disorders (for example where to buy viagra, color blindness) [1]. Also, according to other studies, it was shown that people with genetic disorders of the retina, are at greater risk of developing vision problems after an overdose of sildenafil [2]. In addition, even the recommended dose of sildenafil can cause blurred, increased photosensitivity and changes in color viagra samples vision, the duration of the side effect is not more than one day [3]. However, the case described in a report published in the journal Retinal Cases shows that the loss of visual color and other disorders can last up to a year or more [4].

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An overdose of sildenafil can cause a heart attack, as well as a painfully prolonged erection that can cause the development of gangrene of the penis and its subsequent amputation [5] [3].

Side Effects [edit | edit code]

Headache, “flushes” of blood to the face, dizziness, dyspepsia, nasal congestion, visual disturbances (discoloration of objects (blue / green), increased sensitivity to light, impaired visual clarity) [6].

Interaction [edit | edit code]

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Below are medications that are dangerous to combine with sildenafil –

How Long Does Viagra Last: Sildenafil Wikipedia

Cimetidine, ketoconazole, erythromycin reduce clearance and teva generic viagra increase the concentration of sildenafil in the blood. Enhances the antiplatelet effect of sodium nitroprusside. Enhances the hypotensive effect of nitrates (the combination of sildenafil with nitrates can be fatal), potentially life-threatening co-administration with BMCC, beta-blockers and oral hypoglycemic drugs.

See also [edit | edit code]

Vardenafil (Levitra)

Tadalafil (Cialis best place to buy viagra online)

Udenafil (Ziden)

Avanafil (Stendra)

Which How Long Does It Take For Viagra To Work is beneficial and which are harmful? What fat is good for health?

References [edit | edit code]

Drug Approval Package. Viagra (sildenafil citrate) (English). U.S. Food and Drug Administration (March 27, 1998). The appeal date is September 26, 2015.

Sildenafil (English). Drugs.com. The appeal date is September 26, 2015.

Sildenafil (Neopr.). Encyclopedia of drugs and pharmaceutical goods. Radar Patent. – Instruction, application and formula.

Sildenafil, Tadalafil, Vardenafil – Labels updated with NAION information .. FDA Statement. United States Food and Drug Administration, July 8, 2005 (English). WHO Pharmaceuticals Newsletter 2005, No. 03. Date of appeal September 27, 2015.

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